.one-portal{color:var(--ink);background:var(--paper)}.one-portal .one-portal__viewport{position:relative;width:100%;height:clamp(450px,38vw,580px);isolation:isolate}.one-portal .one-portal__viewport canvas{width:100%;height:100%;position:absolute;inset:0;z-index:1;transition:opacity .24s cubic-bezier(.23,1,.32,1)}.one-portal .one-portal__caption{position:absolute;top:26px;z-index:2;pointer-events:none}.one-portal .one-portal__caption--in{left:1%}.one-portal .one-portal__caption--out{right:1%;text-align:right}.one-portal .one-portal__caption h3{display:inline-flex;align-items:center;justify-content:center;margin:0;padding:10px 20px;border:1px solid #adc3c3;border-radius:999px;background:transparent;color:#214f5e;font:500 15px/1.2 var(--sans);letter-spacing:-.015em;white-space:nowrap}.one-portal .one-portal__bottom{border-top:1px solid var(--line);padding:20px 0;display:flex;align-items:center;justify-content:space-between;gap:24px}.one-portal .one-portal__types{display:flex;flex-wrap:wrap;gap:12px 19px;font-size:13px;line-height:1.5;color:var(--dim)}.one-portal .one-portal__types>span{display:inline-flex;gap:6px;align-items:center}.one-portal .one-portal__types i{width:5px;height:5px;border-radius:50%}.one-portal .one-portal__accessible{position:absolute;width:1px;height:1px;overflow:hidden;clip-path:inset(50%)}.one-portal .one-portal__fallback{position:absolute;inset:0;display:grid;place-items:center;visibility:hidden}.one-portal .one-portal__fallback svg{width:100%;height:100%}.one-portal .one-portal__poster--portrait{display:none}.one-portal[data-failed=true] .one-portal__fallback{visibility:visible}@media(max-width:900px){.one-portal .one-portal__bottom{gap:16px}.one-portal .one-portal__types{max-width:470px;gap:10px 13px}}@media(max-width:650px){.one-portal .one-portal__viewport{height:clamp(300px,50vw,360px)}.one-portal .one-portal__caption{top:8px}.one-portal .one-portal__caption h3{padding:7px 10px;font-size:12px}.one-portal .one-portal__bottom{flex-direction:column;align-items:stretch;padding-top:16px}.one-portal .one-portal__types{justify-content:center;gap:10px 12px;font-size:12px}}@media(max-width:430px){.one-portal .one-portal__viewport{height:clamp(240px,70vw,320px)}}@media(prefers-reduced-motion:reduce){.one-portal .one-portal__viewport canvas{transition:none}}.proteus.pfPage{--pfNav:76px;--pfRailH:46px;--pfBarH:34px;--pfPadT:calc(var(--pfNav) + clamp(4px,1vh,16px));--pfPadB:clamp(44px,5vh,72px);--pfGap:clamp(10px,1.6vh,20px);--pfChrome:calc( var(--pfPadT) + var(--pfRailH) + var(--pfGap) + var(--pfGap) + var(--pfBarH) + var(--pfPadB) )}.proteus .pfMain{flex:1;display:block}.proteus .pfIntro{padding:clamp(46px,8vh,92px) 0 clamp(28px,4.6vh,52px)}.proteus .pfStage{position:relative;overflow:hidden;background:var(--paper);border-top:1px solid var(--line);padding:var(--pfPadT) 0 var(--pfPadB)}.proteus .pfStageIn{display:flex;flex-direction:column}.proteus .pfRail{flex:0 0 auto;height:var(--pfRailH);display:flex;flex-direction:column;justify-content:flex-end;gap:12px}.proteus .pfWords{list-style:none;display:flex;margin:0;padding:0}.proteus .pfWord{position:relative;height:13px;flex:0 0 auto;min-width:0}.proteus .pfWord:before{content:"";position:absolute;left:0;top:-5px;bottom:-14px;width:1px;background:var(--line)}.proteus .pfWordDim,.proteus .pfWordInk{position:absolute;left:11px;top:0;font-family:var(--mono);font-size:11px;line-height:13px;letter-spacing:.24em;text-transform:uppercase;white-space:nowrap}.proteus .pfWordDim{color:var(--dim)}.proteus .pfWordInk{color:var(--ink)}.proteus .pfRailTrack{position:relative;display:block;height:2px;background:var(--line)}.proteus .pfRailFill{position:absolute;inset:0;background:var(--ink);transform:scaleX(0);transform-origin:left center}.proteus .pfViz{margin-top:var(--pfGap);display:flex;align-items:center;justify-content:center}.proteus .pfBoard{position:relative;overflow:hidden;aspect-ratio:1280 / 580;width:100%}.proteus .pfViz .pfBoard{width:min(100%,calc((max(420px,100svh) - var(--pfChrome)) * 1280 / 580))}.proteus .pfCircuit{position:absolute;inset:0;width:100%;height:100%;display:block}.proteus .pfNodes{position:absolute;inset:0;container-type:size}.proteus .pfCampaign{position:absolute;inset:0}.proteus .pfCard{position:absolute;display:flex;flex-direction:column;background:var(--paper2);border:1px solid var(--line);border-radius:6px;overflow:hidden}.proteus .pfCard[data-shape=side]{flex-direction:row}.proteus .pfCard[data-shape=list]{flex-direction:column-reverse}.proteus .pfCardFig{position:relative;flex:0 0 auto;border-bottom:1px solid var(--line)}.proteus .pfCard[data-shape=side] .pfCardFig{height:100%;border-bottom:0;border-right:1px solid var(--line)}.proteus .pfCardBars{position:relative;flex:0 0 auto;min-height:0}.proteus .pfCard[data-shape=list] .pfCardBars{border-top:1px solid var(--line)}.proteus .pfCard[data-shape=side] .pfCardBars{flex:1 1 auto;height:100%}.proteus .pfCardBar{position:absolute;inset:0;display:flex;align-items:center;gap:.9em;padding:0 .9em 0 1.1em;min-width:0}.proteus .pfCardBar:before{content:"";position:absolute;left:0;top:22%;bottom:22%;width:2px;background:var(--dim)}.proteus .pfCardBar[data-accent=blue]:before{background:var(--blue)}.proteus .pfCardBar[data-accent=teal]:before{background:var(--teal)}.proteus .pfCardBar[data-accent=clay]:before{background:var(--clay)}.proteus .pfCardBar[data-accent=ink]:before{background:var(--ink)}.proteus .pfCardLab{font-family:var(--mono);font-size:12px;font-size:1.02cqw;letter-spacing:.1em;color:var(--ink);white-space:nowrap;overflow:hidden;text-overflow:ellipsis}.proteus .pfCardSub{font-family:var(--mono);font-size:9px;font-size:.74cqw;letter-spacing:.14em;color:var(--dim);margin-left:auto;white-space:nowrap}.proteus .pfCardBody{list-style:none;flex:1 1 auto;min-height:0;padding:1em .9em .5em 1.1em;display:flex;flex-direction:column;justify-content:space-between;gap:.5em}.proteus .pfCardBody li{font-family:var(--mono);font-size:9px;font-size:.74cqw;letter-spacing:.13em;color:var(--dim);border-top:1px solid var(--line);padding-top:.55em}.proteus .pfCardFig{--pfFrameW:100%}.proteus .pfFigFrame{position:absolute;top:0;bottom:0;left:50%;width:var(--pfFrameW);margin-left:calc(var(--pfFrameW) * -.5);overflow:hidden;background:var(--paper)}.proteus .pfFig{position:absolute;inset:0;background-image:var(--pfSheet, none);background-repeat:no-repeat;background-size:calc(var(--pfFrames) * 100%) 100%;background-position:0% 0%;animation:pfSpin var(--pfSpin,2s) steps(var(--pfFrames),jump-none) infinite}@keyframes pfSpin{0%{background-position:0% 0%}to{background-position:100% 0%}}.proteus .pfCircuit text{font-family:var(--mono);fill:var(--ink)}.proteus .pfLink{stroke:var(--line);stroke-width:1;fill:none}.proteus .pfArrow{stroke:var(--line);stroke-width:1.4;fill:none;stroke-linecap:round;stroke-linejoin:round}.proteus .pfLink[data-accent=blue],.proteus .pfArrow[data-accent=blue]{stroke:var(--blue)}.proteus .pfLink[data-accent=teal],.proteus .pfArrow[data-accent=teal]{stroke:var(--teal)}.proteus .pfLink[data-accent=clay],.proteus .pfArrow[data-accent=clay]{stroke:var(--clay)}.proteus .pfChipBox{fill:var(--paper2);stroke:var(--line);stroke-width:1}.proteus .pfChipTag{font-size:11.5px;letter-spacing:.1em;fill:var(--dim)}.proteus .pfChipTrack{stroke:var(--line);stroke-width:1}.proteus .pfChipBar{fill:var(--teal);fill-opacity:.52}.proteus .pfChipKill{fill:none;stroke:var(--clay);stroke-width:1}.proteus .pfChipPick rect{fill:none;stroke:var(--clay);stroke-width:1}.proteus .pfChipPick .pfChipTab{fill:var(--clay);stroke:none}.proteus .pfChipStrike{stroke:var(--clay);stroke-width:1;fill:none}.proteus .pfBBox{fill:var(--paper2);stroke:var(--line);stroke-width:1}.proteus .pfBLab{font-size:12.5px;letter-spacing:.055em;fill:var(--ink)}.proteus .pfBBar{fill:var(--teal);fill-opacity:.5}.proteus .pfFleet{position:absolute;inset:0;overflow:hidden}.proteus .pfFleetTrack{position:absolute;top:0;left:0;width:100%;height:200%;transform:translateZ(0);animation:pfDrift var(--pfDrift,21s) linear infinite;animation-play-state:paused}.proteus .pfFleetTile{display:block;width:100%;height:50%}@keyframes pfDrift{0%{transform:translateZ(0)}to{transform:translate3d(0,-50%,0)}}.proteus .pfFleetHead{position:absolute;inset:0;display:flex;align-items:center;pointer-events:none}.proteus .pfFleetHeadT{margin-left:4%;width:35%;font-family:var(--serif);font-weight:440;font-size:5.1cqw;line-height:.98;letter-spacing:-.012em;color:var(--ink)}.proteus .pfSeq:not(.is-off):not(.is-done) .pfWordInk,.proteus .pfSeq:not(.is-off):not(.is-done) .pfCardBar,.proteus .pfSeq:not(.is-off):not(.is-done) .pfFigFrame,.proteus .pfSeq:not(.is-off):not(.is-done) .pfArrow{will-change:opacity}.proteus .pfSeq:not(.is-off):not(.is-done) .pfRailFill,.proteus .pfSeq:not(.is-off):not(.is-done) .pfCampaign,.proteus .pfSeq:not(.is-off):not(.is-done) g[data-campaign-s]{will-change:transform}.proteus .pfSeq:not(.is-off):not(.is-done) .pfFleetHeadT{will-change:transform,opacity}.proteus .pfSeq.is-coda:not(.is-off) .pfFleetTrack{will-change:transform}.proteus .pfSeq.is-coda:not(.is-off) .pfFleetTrack{animation-play-state:running}.proteus .pfSeq.is-coda .pfFig,.proteus .pfSeq.is-off .pfFig{animation-play-state:paused}.proteus .pfBar{flex:0 0 auto;height:var(--pfBarH);margin-top:var(--pfGap);display:flex;align-items:center;justify-content:flex-end}.proteus .pfReplay{position:relative;appearance:none;background:none;border:1px solid var(--line);border-radius:999px;padding:6px 15px;font-family:var(--mono);font-size:10px;line-height:1.2;letter-spacing:.2em;text-transform:uppercase;color:var(--dim);cursor:pointer;transition:color .2s,border-color .2s}.proteus .pfReplay:after{content:"";position:absolute;left:0;right:0;top:50%;height:44px;margin-top:-22px}@media(hover:hover){.proteus .pfReplay:hover{color:var(--ink);border-color:var(--dim)}}.proteus .pfReplay:active{color:var(--ink);border-color:var(--dim)}.proteus .pfReplay:focus-visible{outline:1px solid var(--ink);outline-offset:3px}.proteus .pfSeq.is-done .pfReplay{color:var(--ink);border-color:var(--dim)}.proteus .pfRest{display:none;border-top:1px solid var(--line)}.proteus .pfRestList{list-style:none}.proteus .pfRestItem{border-bottom:1px solid var(--line);padding:clamp(24px,3.4vh,44px) 0}.proteus .pfRestWord{min-height:13px;font-family:var(--mono);font-size:11px;line-height:13px;letter-spacing:.24em;text-transform:uppercase;color:var(--dim)}.proteus .pfRestViz{margin-top:clamp(14px,2vh,26px)}.proteus .pfRest .pfFig,.proteus .pfRest .pfFleetTrack{animation:none}.proteus .pfPipeline{padding:clamp(56px,9vh,110px) 0 clamp(48px,7vh,88px);background:var(--band);border-top:1px solid var(--line);border-bottom:1px solid var(--line);--pfPipeLab:32%;--pfPipeCol:17%;--pfRowH:74px}.proteus .pfPipeH{font-family:var(--serif);font-weight:440;font-size:clamp(30px,4vw,52px);line-height:1.04}.proteus .pfPipeLine{font-family:var(--sans);font-size:17px;line-height:1.5;color:var(--dim);margin-top:12px}.proteus .pfPipeScroll{margin-top:clamp(30px,4.4vh,54px)}.proteus .pfPipeHead{display:grid;grid-template-columns:var(--pfPipeLab) repeat(4,var(--pfPipeCol));align-items:end;padding-bottom:14px}.proteus .pfPipeHead span{font-family:var(--mono);font-size:10px;letter-spacing:.18em;text-transform:uppercase;color:var(--ink);text-align:center}.proteus .pfPipeHead .pfPipeHeadProg{text-align:left;color:var(--dim)}.proteus .pfPipeBody{position:relative;display:flex;flex-direction:column;gap:12px}.proteus .pfPipeCols{position:absolute;inset:0;pointer-events:none;z-index:1}.proteus .pfPipeCols i{position:absolute;top:-14px;bottom:0;width:1px;background:var(--line)}.proteus .pfRowCols{display:none;position:absolute;inset:0;pointer-events:none}.proteus .pfRowCols i{position:absolute;top:-5px;bottom:-5px;width:1px;background:var(--line)}.proteus .pfRow{position:relative;display:grid;grid-template-columns:var(--pfPipeLab) 1fr;align-items:center;min-height:var(--pfRowH);background:var(--paper);border:1px solid var(--line);border-radius:999px}.proteus .pfRowLab{display:flex;align-items:baseline;justify-content:space-between;gap:14px;min-width:0;padding:0 22px 0 30px}.proteus .pfRowId{display:flex;align-items:baseline;gap:12px;min-width:0}.proteus .pfRow .code{font-family:var(--mono);font-size:10px;letter-spacing:.2em;color:var(--dim);flex:0 0 auto}.proteus .pfRow .nm{font-family:var(--serif);font-weight:500;font-size:19px;line-height:1.1;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}.proteus .pfRow .ind{font-family:var(--sans);font-size:13px;color:var(--dim);white-space:nowrap;flex:0 0 auto}.proteus .pfRowBars{position:relative;align-self:stretch;z-index:2}.proteus .pfPipeBar{position:absolute;left:0;top:calc(50% - 7px);height:14px;border-radius:999px;background:var(--blue);opacity:.62;transform-origin:left center;transform:scaleX(0)}.proteus .pfPipeline.is-drawing .pfPipeBar{will-change:transform}.proteus .pfRow[data-ghost] .nm{font-family:var(--sans);font-weight:400;font-size:14.5px;color:var(--dim)}@media(max-width:960px){.proteus .pfSeq[data-geo=d],.proteus .pfRest[data-geo=d]{display:none}}@media(min-width:961px){.proteus .pfSeq[data-geo=m],.proteus .pfRest[data-geo=m]{display:none}}@media(max-width:960px){.proteus.pfPage{--pfNav:66px;--pfRailH:38px;--pfBarH:30px;--pfGap:clamp(8px,1.2vh,14px);--pfPadB:clamp(26px,3.4vh,40px)}.proteus .pfIntro{padding:clamp(34px,6vh,64px) 0 clamp(22px,3.4vh,40px)}.proteus .pfViz .pfBoard{width:min(100%,max(294px,calc((100svh - var(--pfChrome)) * 400 / 660)))}.proteus [data-geo=m] .pfWords{position:relative;display:block;height:13px}.proteus [data-geo=m] .pfWord{position:absolute;left:0;top:0}.proteus [data-geo=m] .pfWord:before{display:none}.proteus [data-geo=m] .pfWordDim{display:none}.proteus [data-geo=m] .pfWordInk{left:0}.proteus .pfBoard[data-geo=m] .pfCardLab{font-size:min(3.4cqw,13px)}.proteus .pfBoard[data-geo=m] .pfCardSub,.proteus .pfBoard[data-geo=m] .pfCardBody li{font-size:min(3.15cqw,10.6px)}.proteus .pfBoard[data-geo=m] .pfChipTag{font-size:12.65px}.proteus .pfBoard[data-geo=m] .pfBLab{font-size:12.6px}.proteus .pfBoard[data-geo=m] .pfCardBar{flex-direction:column;align-items:stretch;justify-content:center;gap:.16em;padding:0 .7em 0 .85em}.proteus .pfBoard[data-geo=m] .pfCardSub{margin-left:0}.proteus .pfBoard[data-geo=m] .pfCardBody{padding:.6em .85em .4em 1.05em;gap:.3em}.proteus .pfBoard[data-geo=m] .pfFleetHead{align-items:flex-start}.proteus .pfBoard[data-geo=m] .pfFleetHeadT{margin:6% 0 0 6%;width:74%;font-size:9cqw;background:var(--paper);padding:14px 16px 16px;-webkit-box-decoration-break:clone;box-decoration-break:clone}}@media(max-width:560px){.proteus [data-geo=m] .pfViz,.proteus .pfRest[data-geo=m] .pfRestViz{margin-inline:calc(-1*clamp(24px,4vw,64px))}}@media(max-width:860px){.proteus .pfPipeH{font-size:clamp(30px,8vw,44px)}.proteus .pfPipeLine{font-size:15.5px}.proteus .pfPipeHead{grid-template-columns:repeat(4,1fr);padding:0 13px 10px}.proteus .pfPipeHead span{letter-spacing:.05em}.proteus .pfPipeHead .pfPipeHeadProg{display:none}.proteus .pfPipeBody{gap:10px}.proteus .pfPipeCols{display:none}.proteus .pfRowCols{display:block}.proteus .pfRow{grid-template-columns:1fr;align-items:stretch;gap:11px;min-height:0;border-radius:16px;padding:15px 12px 17px}.proteus .pfRowLab{padding:0;gap:10px 12px;flex-wrap:wrap}.proteus .pfRow .nm{font-size:17px;white-space:normal}.proteus .pfRow .ind{font-size:12.5px}.proteus .pfRowBars{height:18px;align-self:auto}}@media(prefers-reduced-motion:reduce){.proteus .pfSeq{display:none}.proteus .pfRest{display:block}.proteus .pfPipeBar{transform:none}.proteus .pfFig,.proteus .pfFleetTrack{animation:none}}@font-face{font-family:Instrument Sans;font-style:normal;font-weight:400 700;font-display:swap;src:url(/fonts/instrument-sans-latin-variable.woff2) format("woff2");unicode-range:U+0000-00FF,U+0131,U+0152-0153,U+02BB-02BC,U+02C6,U+02DA,U+02DC,U+0304,U+0308,U+0329,U+2000-206F,U+20AC,U+2122,U+2191,U+2193,U+2212,U+2215,U+FEFF,U+FFFD}@font-face{font-family:"Source Serif 4";font-style:normal;font-weight:400 600;font-display:swap;src:url(/fonts/source-serif-4-latin-variable.woff2) format("woff2");unicode-range:U+0000-00FF,U+0131,U+0152-0153,U+02BB-02BC,U+02C6,U+02DA,U+02DC,U+0304,U+0308,U+0329,U+2000-206F,U+20AC,U+2122,U+2191,U+2193,U+2212,U+2215,U+FEFF,U+FFFD}.proteus.one-page{--paper: #e8ede6;--paper2: #e7eeea;--band: #e0e9e7;--ink: #06344f;--dim: #526c78;--line: #b7cccf;--blue: #075385;--teal: #378d86;--clay: #9b7951;--accent: #075385;--serif: "Source Serif 4", Georgia, serif;--sans: "Instrument Sans", Arial, sans-serif;--mono: "Instrument Sans", Arial, sans-serif;--neo-quote: var(--serif);--neo-body: var(--sans);--one-gutter: clamp(24px, 4.5vw, 88px);--pfNav: 0px;--pfPadT: 24px;overflow-x:clip;font-family:var(--sans);font-optical-sizing:auto}.one-page a{color:inherit;text-decoration:none}.one-page button{font:inherit;cursor:pointer;touch-action:manipulation}.one-page button:disabled{cursor:default;opacity:.55}.one-page :is(a,button,summary):focus-visible{outline:2px solid currentColor;outline-offset:5px}.one-page .one-skip{position:absolute;top:-100px;left:20px;background:var(--paper);color:var(--ink);padding:16px;z-index:20}.one-page .one-skip:focus{top:10px}.one-header{background:#054b7b;color:var(--paper);padding:30px var(--one-gutter);display:flex;align-items:center;justify-content:space-between;gap:30px}.one-brand .neo-brand{display:inline-flex;gap:11px;align-items:center}.one-brand .neo-brand__symbol{width:29px;height:32px;fill:currentColor}.one-brand .neo-brand__name{font:500 29px/1 var(--sans);letter-spacing:-.055em}.one-brand sup{font-size:9px;vertical-align:super;margin-left:3px}.one-header nav,.one-footer nav{display:flex;gap:32px;font-size:14px}.one-header [aria-current]{text-decoration:underline;text-underline-offset:6px}.site-app:has(.one-page) .site-header:not(.is-scrolled){background:#175cbd;color:#fffdf8}.one-page .one-opening{position:relative;z-index:1;padding:24px 0 16px;background:#175cbd;-webkit-font-smoothing:antialiased}.one-page .one-opening:after{position:absolute;z-index:0;inset:0 0 -24px;background:linear-gradient(180deg,#175cbd 0%,#175cbd 30%,#3773c3 40%,#5b89c8 50%,#80a2cd 60%,#a3bad2 70%,#c1cfd7 80%,#d8dfdc 90%,var(--paper) 100%);content:"";pointer-events:none}.one-page .one-opening__title{position:relative;z-index:1;margin:0 0 18px;color:#fffdf8;font:450 clamp(36px,3.4vw,48px)/1.04 var(--sans);letter-spacing:-.055em;text-align:center}.one-page .one-page__title{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip-path:inset(50%);white-space:nowrap;border:0}.one-system{scroll-margin-top:12px}.one-page .one-tabs{position:relative;z-index:1;display:flex;width:680px;max-width:calc(100% - 2 * var(--one-gutter));gap:6px;margin-inline:auto;padding:8px;border:1px solid #9fbdc8;border-radius:999px;background:var(--paper)}.one-page .one-tabs>a{position:relative;display:flex;flex:1 1 0;align-items:center;justify-content:center;min-width:0;min-height:60px;padding:16px 24px;text-align:center;background:transparent;border:0;border-radius:999px;color:var(--dim);transition:color .18s ease,background-color .18s ease}.one-page .one-tabs>a[aria-selected=true]{color:#fff;background:#2549ed}.one-page .one-tabs>a:focus-visible{outline:2px solid #2549ed;outline-offset:3px}.one-tabs__name{display:block;font:400 22px/1.25 var(--sans);letter-spacing:-.025em;white-space:nowrap}.one-tabs__name svg{display:none}.one-page .one-tabs__role{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip-path:inset(50%);white-space:nowrap;border:0}@media(hover:hover)and (pointer:fine){.one-page .one-tabs>a[aria-selected=false]:hover{color:#305963;background:#dce7e7}}.one-page .one-tabs>a[aria-selected=false]:active{background:#d1dfe3}.one-page .one-panel{padding:22px var(--one-gutter) 0;scroll-margin-top:24px}.one-panel[hidden]{display:none}.one-page .one-panel>:is(.one-portal,.pythia-circuit,.one-panel__intro,.one-panel__note,.one-loading,.one-clinical-summary){max-width:1520px;margin-inline:auto}.one-page .one-panel__intro{display:grid;grid-template-columns:1fr 1fr;gap:clamp(32px,8vw,128px);align-items:start;padding-block:38px 18px}.one-panel__intro h2{max-width:21ch;font:400 clamp(30px,3vw,44px)/1.12 var(--serif);letter-spacing:-.035em}.one-panel__intro>p{max-width:50ch;font-size:17px;line-height:1.65;padding-top:5px;color:var(--dim)}.one-panel__note{display:grid;grid-template-columns:1fr 1fr;gap:clamp(32px,8vw,128px);padding:34px 0 56px}.one-panel__note>h3{margin:0;font:400 25px/1.25 var(--serif);letter-spacing:-.02em}.one-panel__note>span{max-width:57ch;font-size:16px;line-height:1.65;color:var(--dim)}.one-graph{color:#e9f1e8;background:#064671}.one-graph__toolbar{display:flex;align-items:center;justify-content:space-between;gap:20px;padding:24px 30px 0}.one-graph__toolbar>div{display:flex;gap:4px;border:1px solid #5c88a1;padding:4px;border-radius:30px}.one-graph__toolbar button{border:0;padding:10px 17px;border-radius:24px;background:transparent;color:#d2e4e7;font-size:12px}.one-graph__toolbar button[aria-pressed=true]{background:#e5eeea;color:#08436a}.one-graph__toolbar>span{color:#a1c4d7;font-size:11px}.one-graph__field{position:relative;padding:0 8px 34px}.one-graph__field>svg{display:block;width:100%;overflow:visible}.one-graph__web{fill:none;stroke:#74abcc;stroke-width:.75;opacity:.34}.one-graph__nodes{fill:#c2e5f2}.one-graph__exploration{fill:none;stroke:#66c8dd;stroke-width:2}.one-graph__exploration .is-searching path{stroke-dasharray:7 10;animation:one-search 1.5s linear infinite;animation-play-state:paused}.one-graph[data-running=true] .one-graph__exploration .is-searching path{animation-play-state:running}.one-graph__route{fill:none;stroke:#ece4a6;stroke-width:3;stroke-linecap:round;stroke-linejoin:round}.one-graph__route .is-tracing{animation:one-route 1.65s ease both;animation-play-state:paused}.one-graph[data-running=true] .one-graph__route .is-tracing{animation-play-state:running}@keyframes one-route{0%{stroke-dashoffset:1}to{stroke-dashoffset:0}}.one-graph__hops{fill:#ece4a6}.one-graph__waypoint>circle{fill:#064671;stroke:#739bb3;stroke-width:2}.one-graph__waypoint[data-reached=true]>circle{fill:#f0e8ae;stroke:#f0e8ae}.one-graph__waypoint .one-graph__halo{fill:none!important;opacity:.35;stroke-width:1}.one-graph__waypoint rect{fill:#064671}.one-graph__waypoint text{fill:#e6eee9;font:16px var(--sans)}.one-graph__legend{display:flex;justify-content:center;gap:30px;font-size:10px;color:#b0cfda}.one-graph__legend>span{display:flex;align-items:center;gap:8px}.one-graph__legend>span:before{content:"";width:17px;height:1px;background:#75a8c3}.one-graph__legend>span:nth-child(2):before{background:#66c8dd}.one-graph__legend>span:nth-child(3):before{background:#ece4a6;height:2px}.one-graph__transport{display:flex;justify-content:space-between;align-items:center;gap:25px;padding:27px 30px;border-top:1px solid #346b8c}.one-graph__phase{display:flex;align-items:flex-start;gap:28px}.one-graph__phase>span{padding-top:5px;font-size:11px;color:#98bed1;white-space:nowrap}.one-graph__phase h3{font:400 clamp(24px,2.5vw,33px)/1.1 var(--serif);letter-spacing:-.025em}.one-graph__phase p{font-size:12px;color:#b9d4df;margin-top:10px;line-height:1.5}.one-graph__playback{display:flex;gap:8px;flex-shrink:0}.one-graph__playback button{border:1px solid #608ea6;border-radius:30px;min-width:68px;min-height:44px;color:#e9f1e8;background:transparent;font-size:12px;padding:8px 12px}.one-panel--proteus .pfSeq,.one-panel--proteus .pfRest{margin-inline:calc(-1 * var(--one-gutter))}.one-page .pfStage{border-top:0}.one-page .pfWordDim,.one-page .pfWordInk,.one-page .pfRestWord,.one-page .pfReplay{letter-spacing:.01em;text-transform:none;font-size:13px}.one-page .pfCardLab,.one-page .pfCardSub,.one-page .pfCardBody li{font-family:var(--sans);letter-spacing:0}.one-page .pfCardLab{font-weight:500;color:#254c5b}.one-page .pfCardSub,.one-page .pfCardBody li{color:#496771}.one-page .pfCard{border-radius:3px}.one-page .pfCardFig{border-color:#c6d5d4}.one-page .pfFig{mix-blend-mode:normal;filter:none}.one-page .pfFigFrame{background:var(--paper)}.one-page .pfPipeLine{display:none}.one-panel--pythia .pythia-process{padding-bottom:54px}.one-loading,.one-clinical-summary{padding:70px 0;font-size:16px;line-height:1.7}.one-page>main{padding-bottom:clamp(64px,5vw,80px)}.one-page .one-contact{width:min(1520px,calc(100% - 2 * var(--one-gutter)));margin:32px auto 0}.proteus .one-footer{background:#054b7b;color:#e7efea;display:flex;gap:40px;justify-content:space-between;align-items:center;padding:38px var(--one-gutter)}.one-footer>p{font-size:13px;color:#b8d4df}@keyframes one-search{to{stroke-dashoffset:-34}}@media(max-width:900px){.one-header nav,.one-footer nav{gap:20px;font-size:12px}.one-graph__transport{align-items:flex-start}.one-graph__phase{gap:16px}.one-footer>p{display:none}}@media(max-width:650px){.one-header{padding-block:24px;gap:20px}.one-header nav{gap:16px}.one-header nav a:nth-child(2){display:none}.one-brand .neo-brand__symbol{width:23px;height:27px}.one-brand .neo-brand__name{font-size:24px}.one-brand .neo-brand{gap:8px}.one-page .one-opening{padding:18px 0 12px}.one-page .one-opening__title{margin-bottom:16px}.one-page .one-tabs{max-width:calc(100% - 24px)}.one-page .one-panel{padding-top:18px}.one-page .one-panel__intro{grid-template-columns:1fr;gap:20px;padding-block:28px 10px}.one-panel__intro h2{font-size:32px}.one-panel__intro p{font-size:16px}.one-graph{margin-inline:calc(-1 * var(--one-gutter))}.one-graph__toolbar{padding:23px 18px 8px;flex-direction:column;gap:12px;align-items:flex-start}.one-graph__toolbar>div{gap:0}.one-graph__toolbar button{font-size:11px;padding-inline:16px}.one-graph__toolbar>span{align-self:flex-end;font-size:10px}.one-graph__field{padding:0 0 25px}.one-graph__web{stroke-width:.8;opacity:.38}.one-graph__waypoint text{font-size:17px}.one-graph__route{stroke-width:2.8}.one-graph__legend{gap:12px;font-size:8px;flex-wrap:wrap;padding:0 16px}.one-graph__legend>span{gap:5px}.one-graph__legend>span:before{width:12px}.one-graph__transport{padding:24px;flex-direction:column;gap:20px}.one-graph__phase{gap:14px}.one-graph__phase>span{font-size:9px}.one-graph__phase h3{font-size:27px}.one-graph__phase p{font-size:11px}.one-graph__playback{align-self:flex-end}.one-panel__note{grid-template-columns:1fr;gap:17px;padding:28px 0 38px}.one-page .one-contact{margin:28px var(--one-gutter) 0}.proteus .one-footer{flex-wrap:wrap;gap:30px;padding-block:30px}.one-footer nav{gap:24px}}@media(max-width:640px){.one-page .one-tabs{gap:4px;padding:6px}.one-page .one-tabs>a{min-height:48px;padding:12px 8px}.one-tabs__name{font-size:16px}}@media(prefers-reduced-motion:reduce){.one-graph__route path,.one-page .one-tabs>a{transition:none}.one-graph .is-searching path{animation:none}}.proteus .one-footer{min-height:0;flex-direction:row}.proteus .one-footer:before{display:none}@media(prefers-reduced-motion:reduce){.one-graph__route .is-tracing{animation:none}}.one-graph[data-reduced-motion=true] .one-graph__route .is-tracing,.one-graph[data-reduced-motion=true] .one-graph__exploration .is-searching path{animation:none}.site-app .one-page .one-panel{scroll-margin-top:100vh;scroll-margin-top:100svh}